Biochem-Peptides

🧬 GHK-Cu – Copper-Binding Tripeptide for Regenerative & Anti-Aging Research Synonyms: Glycyl-L-Histidyl-L-Lysine Copper Complex, Copper Tripeptide-1 CAS Number: 89030-95-5 Sequence: Gly-His-Lys·Cu²⁺ Molecular Weight: ~403.9 Da (complexed form) Form: Lyophilized powder Purity: ≥98% (HPLC) Research Use Only. This compound is not approved for human or veterinary use.. --- Description: GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine, histidine, and lysine, complexed with a divalent copper ion (Cu²⁺). It is endogenously present in plasma, saliva, and urine, with levels declining significantly with age. GHK-Cu is under active investigation for its role in tissue remodeling, wound healing, angiogenesis, and anti-inflammatory signaling, making it a versatile scaffold in regenerative and dermatological research. --- ⚙️ Mechanism of Action: GHK-Cu exerts its biological effects through multiple converging pathways: • Collagen & ECM Remodeling: Stimulates synthesis of collagen, elastin, glycosaminoglycans, and decorin • Anti-Inflammatory Modulation: Downregulates pro-inflammatory cytokines (e.g., TNF-α, IL-6) • Angiogenesis Support: Provides bioavailable copper essential for vascular endothelial growth • Wound Healing: Enhances fibroblast activity and promotes scarless tissue regeneration • Neuroregeneration: Encourages axonal outgrowth and synaptic repair in neuronal models • DNA Repair & Epigenetic Resetting: Shown to influence gene expression linked to cellular rejuvenation Its ability to act as a tissue-specific signaling molecule makes it a compelling candidate in both cosmetic and therapeutic research domains. --- 📈 Research Applications: GHK-Cu is being explored in preclinical and in vitro models for: • Skin regeneration and anti-aging • Hair follicle stimulation and pigmentation • Wound healing and scar reduction • Neuroinflammation and nerve repair • Osteogenesis and bone remodeling • UV protection and photodamage mitigation Its non-hormonal, non-immunogenic profile makes it suitable for long-term regenerative studies. --- 📦 Packaging & Handling: • Supplied as a sterile-filtered lyophilized peptide–metal complex • Store at –20°C, protected from light and moisture • Reconstitute with bacteriostatic water, saline, or appropriate buffer • Store in the refrigerator once in a reconstituted solution to preserve stability 2-8 °C

🧬 BPC-157 – Regenerative Peptide for Angiogenesis, Tissue Repair & Gastrointestinal Research Synonyms: Body Protection Compound-157, PL 14736 CAS Number: 137525-51-0 Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Molecular Weight: ~1419.5 Da Form: Lyophilized powder Purity: ≥98% (HPLC) Research Use Only. This compound is not approved for human or veterinary use.. --- Description: BPC-157 is a synthetic pentadecapeptide derived from a partial sequence of Body Protection Compound (BPC), a protein naturally found in human gastric juice. It is under active investigation for its multifaceted regenerative properties, particularly in models of muscle, tendon, nerve, and gastrointestinal repair. BPC-157 is known to modulate angiogenesis, collagen synthesis, and inflammatory signaling, making it a versatile scaffold in wound healing and organoprotection research. --- ⚙️ Mechanism of Action: Although not fully elucidated, BPC-157 is believed to act through several converging pathways: • VEGF Upregulation: Promotes angiogenesis and microvascular repair • Fibroblast Activation: Enhances collagen production and extracellular matrix remodeling • Anti-Inflammatory Modulation: Downregulates pro-inflammatory cytokines (e.g., TNF-α, IL-6) • Neuroregeneration: Supports axonal outgrowth and synaptic repair in peripheral nerve models • Gastrointestinal Protection: Accelerates healing of ulcers and mitigates NSAID-induced mucosal damage Its systemic effects have been observed in both local injury models and systemic inflammatory conditions. --- 📈 Research Applications: BPC-157 is being explored in preclinical and in vitro models for: • Tendon-to-bone healing and ligament repair • Skeletal muscle regeneration and myocyte protection • Gastrointestinal mucosal healing (e.g., IBD, ulcers) • Peripheral nerve injury and neuroinflammation • Joint health and arthritis models • Angiogenesis and ischemic tissue recovery Its non-anabolic, non-hormonal profile makes it suitable for diverse regenerative studies without endocrine disruption. --- 📦 Packaging & Handling: • Supplied as a sterile-filtered lyophilized peptide • Store at –20°C, protected from light and moisture • Reconstitute with bacteriostatic water, acetic acid, or appropriate diluent • Store in the refrigerator once in a reconstituted solution to preserve bioactivity 2-8°C

🧬 Melanotan 1 – Selective MC1R Agonist for Pigmentation Research Synonyms: Afamelanotide, [Nle⁴, D-Phe⁷]-α-MSH, CUV1647 CAS Number: 75921-69-6 Sequence: Ac-Ser-Tyr-Ser-Nle⁴-Glu-His-D-Phe⁷-Arg-Trp-Gly-Lys-Pro-Val-NH₂ Molecular Weight: ~1646.9 Da Form: Lyophilized powder Purity: ≥98% (HPLC) Research Use Only. This compound is not approved for human or veterinary use. --- Description: Melanotan 1 is a synthetic linear peptide analog of alpha-melanocyte-stimulating hormone (α-MSH), engineered to selectively activate the melanocortin 1 receptor (MC1R). This receptor is primarily expressed in melanocytes, where it regulates eumelanin production and UV-induced pigmentation. Melanotan 1 is structurally optimized for enhanced receptor affinity, proteolytic resistance, and prolonged biological activity, making it a valuable tool in pigmentation and photoprotection research. --- ⚙️ Mechanism of Action: Melanotan 1 binds with high specificity to MC1R, initiating a cAMP-mediated signaling cascade that: • Stimulates eumelanin synthesis via upregulation of tyrosinase and related enzymes • Enhances UV-induced pigmentation and melanocyte activation • May reduce UV-induced DNA damage by increasing melanin density Unlike Melanotan 2, MT-1 exhibits minimal off-target activity at MC3R and MC4R, reducing the likelihood of systemic or neuroendocrine effects in research models. --- 📈 Research Applications: Melanotan 1 is under investigation in preclinical and in vitro models for: • Skin pigmentation and photoprotection • Melanocyte biology and UV response • Eumelanin vs pheomelanin expression ratios • Potential synergy with UVB exposure in pigmentation studies Its receptor selectivity makes it ideal for targeted melanogenesis research without confounding systemic effects. --- 📦 Packaging & Handling: • Supplied as a sterile-filtered lyophilized peptide • Store at –20°C, protected from light and moisture • Reconstitute with bacteriostatic water, acetic acid, or other suitable diluent • Store in the refrigerator once a reconstituted solution to preserve integrity 2-8°C

🧬 PT-141 – Melanocortin Receptor Agonist for Sexual Arousal & Neuroendocrine Research Synonyms: Bremelanotide, Vyleesi, α-MSH Analog CAS Number: 189691-06-3 Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH Molecular Weight: ~1025.2 Da Form: Lyophilized powder or pre-filled auto-injector Purity: ≥98% (HPLC) Research Use Only. This compound is not approved for human or veterinary use.. --- Description: PT-141 is a synthetic melanocortin receptor agonist derived from Melanotan II, designed to selectively activate MC3R and MC4R receptors in the central nervous system. Unlike PDE5 inhibitors, PT-141 works centrally, bypassing vascular pathways and directly stimulating sexual desire and arousal via hypothalamic signaling. It is FDA-approved under the name Bremelanotide for treating hypoactive sexual desire disorder (HSDD) in premenopausal women, and is under investigation for male erectile dysfunction, especially in sildenafil non-responders. --- ⚙️ Mechanism of Action: PT-141 binds to melanocortin receptors in the CNS, particularly MC4R, triggering: • Dopamine release in the medial preoptic area and hypothalamus • Sexual arousal independent of visual or tactile stimulation • Increased genital blood flow via neurogenic vasodilation • Appetite suppression and mild mood elevation in some models Its non-hormonal, non-vascular mechanism makes it a unique scaffold for studying neuroendocrine arousal pathways. --- 📈 Research Applications: PT-141 is under investigation in preclinical and clinical models for: • Female sexual dysfunction (HSDD, FSAD) • Male erectile dysfunction (ED) • Neuroendocrine signaling and dopamine modulation • Appetite regulation and melanocortin pathway mapping • Combination therapy with PDE5 inhibitors or amylin analogs In clinical trials, PT-141 demonstrated statistically significant increases in sexual desire and satisfaction, with onset typically within 30–60 minutes post-injection. --- 🧪 Dosing & Handling (Preclinical): • Typical dose: 1–2 mg SubQ; up to 10 mg in ED models • Onset: ~45 minutes; peak effect at 1–2 hours • Duration: ~6–8 hours • Cycle: No more than 8 doses/month (per FDA guidelines for HSDD) • Reconstitution: Use bacteriostatic water; • Store in the refrigerator once a reconstituted solution to preserve integrity 2-8°C --- 📦 Packaging & Storage: Supplied as lyophilized powder or pre-filled auto-injector pens. Reconstitute under sterile conditions. For research use only