🧬 Ipamorelin – Selective Growth Hormone Secretagogue (GHS)
Synonyms: NNC 26-0161
CAS Number: 170851-70-4
Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Molecular Weight: ~711.9 Da
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. Not for human consumption.
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Description:
Ipamorelin is a synthetic pentapeptide classified as a selective growth hormone secretagogue (GHS) and ghrelin receptor agonist. It is designed to stimulate endogenous growth hormone (GH) release via activation of the GHS-R1a receptor, without significantly affecting cortisol, prolactin, or ACTH levels. This receptor selectivity makes Ipamorelin a valuable tool in research focused on anabolic signaling, tissue regeneration, and age-related GH decline.
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⚙️ Mechanism of Action:
Ipamorelin mimics the action of ghrelin, binding to the GHS-R1a receptor in the pituitary and hypothalamus to:
• Stimulate GH release via somatotroph activation
• Inhibit somatostatin, the natural GH suppressor
• Avoid triggering the hypothalamic-pituitary-adrenal (HPA) axis, minimizing stress hormone elevation
Its short half-life (~2 hours) and clean hormonal profile make it ideal for studying isolated GH effects in metabolic and regenerative models.
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📈 Research Applications:
Ipamorelin is under investigation in preclinical models for:
• Muscle growth and recovery
• Bone mineral density and osteogenesis
• Fat metabolism and body composition
• Anti-aging and GH axis modulation
• Post-injury tissue repair
Its favorable safety profile and receptor specificity distinguish it from earlier GHRPs like GHRP-6 or GHRP-2.
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📦 Packaging & Handling:
• Supplied as a sterile-filtered lyophilized peptide
• Store at –20°C, protected from light and moisture
• Reconstitute with bacteriostatic water or appropriate diluent
• Store in the refrigerator once in a reconstituted solution to preserve bioactivity 2-8°C
SKU: IPA-10MG-VIAL
