Ipamorelin – Technical Brief (For Research-Use-Only)
1. Identity
Ipamorelin is a synthetic growth hormone secretagogue, designed to stimulate the release of growth hormone (GH) from the pituitary gland. It is known for its selective action, meaning it does not significantly affect cortisol or prolactin levels, unlike other GH-releasing peptides.
2. Mechanism of Action
Ipamorelin works by:
- Binding to GHRH receptors: Stimulates the pituitary gland to release GH.
- Mimicking natural GH secretion: Induces a pulsatile release pattern.
- Enhancing muscle growth and recovery: Supports protein synthesis and tissue repair.
3. Uses
Ipamorelin is primarily researched for:
- Muscle growth and recovery: Supports lean muscle development and repair.
- Anti-aging and longevity: Investigated for its role in improving skin elasticity and cellular regeneration.
- Fat loss and metabolic health: May aid in reducing adipose tissue.
- Neuroprotective effects: Potential applications in cognitive health.
3. Dosage
Common research protocols include:
- Subcutaneous injection: 200–300mcg per day.
- Administration: Typically injected before bedtime to align with natural GH cycles.
- Duration: Often used for 8–12 weeks in research settings.
4. Safety Profile
- Common side effects: Mild irritation at the injection site, occasional headaches.
- Precautions: Generally well-tolerated, with minimal reported adverse effects.
- No significant impact on cortisol or prolactin: Unlike other GH secretagogues, Ipamorelin does not cause unwanted hormonal fluctuations.
5. Storage Guidelines
- Before mixing: Store the lyophilized powder in a refrigerator (2–8°C / 36–46°F), protected from light.
- After mixing: Keep refrigerated and use within 30–45 days.
- Room temperature storage: Can be kept at up to 30°C (86°F) for a maximum of 21 days, but should not be returned to refrigeration afterward.
- Do not freeze: Freezing reconstituted vials can degrade the peptide’s integrity.
6. Legality in the UK
Ipamorelin is not approved for human consumption in the UK and is classified as a research chemical. It is available for scientific studies but cannot be legally marketed or sold for human use. Regulatory bodies such as the MHRA (Medicines and Healthcare products Regulatory Agency) have not authorized it for medical applications.
