🧬 AHK-Cu – Copper-Binding Tripeptide for Hair Growth, Skin Remodeling & Anti-Apoptotic Research
Synonyms: Ala-His-Lys-Cu, Copper Tripeptide AHK
CAS Number: Not publicly disclosed
Sequence: Ala-His-Lys (complexed with Cu²⁺)
Molecular Weight: ~340–360 Da (peptide only)
Form: Lyophilized powder or topical solution
Purity: ≥98% (HPLC)
Research Use Only. Not for human consumption.
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Description:
AHK-Cu is a synthetic copper-binding tripeptide composed of alanine, histidine, and lysine, chelated with a copper (II) ion. It is structurally similar to GHK-Cu but exhibits targeted activity in dermal papilla cells, fibroblasts, and vascular endothelial tissue. AHK-Cu is under investigation for its ability to stimulate hair follicle regeneration, enhance extracellular matrix remodeling, and suppress apoptosis in aging or stressed tissues. Its compact structure and copper affinity make it highly bioavailable and suitable for topical or injectable delivery in regenerative research.
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⚙️ Mechanism of Action:
AHK-Cu exerts its effects through multiple pathways:
• VEGF Upregulation: Promotes angiogenesis and microvascular support for hair follicles and dermal tissue.
• Fibroblast Activation: Enhances collagen and elastin synthesis via TGF-β and lysyl oxidase modulation.
• Anti-Apoptotic Signaling: Increases Bcl-2/Bax ratio and suppresses caspase-3 and PARP activity in dermal papilla cells.
• DHT Modulation: May inhibit 5α-reductase activity and downregulate androgen receptor signaling in hair follicles.
• Antioxidant Defense: Copper ion stabilizes superoxide dismutase (SOD) and reduces oxidative stress in skin and scalp tissue.
These mechanisms position AHK-Cu as a localized regenerative agent, ideal for hair restoration, skin rejuvenation, and post-procedure recovery.
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📈 Research Applications:
AHK-Cu is under investigation in preclinical models for:
• Hair follicle regeneration and anagen phase extension
• Dermal remodeling and fibroblast proliferation
• Anti-aging and wrinkle reduction
• Wound healing and scar minimization
• Angiogenesis and microcirculation support
• Combination therapy with GHK-Cu or microneedling protocols
Studies suggest AHK-Cu may increase Type I collagen synthesis by up to 300%, improve follicle density, and reduce apoptotic signaling in stressed dermal environments A C.
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🧪 Dosing & Handling (Preclinical):
• Typical dose: 1–2 mg per application (topical or injectable)
• Cycle: Daily or alternate-day use for 4–12 weeks
• Delivery: Topical serum, microneedling solution, or SubQ injection
• Reconstitution: Use bacteriostatic water or saline, avoid acidic solvents
• Store in the refrigerator once a reconstituted solution to preserve integrity 2-8°C
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📦 Packaging & Storage:
Supplied as sterile lyophilized powder or pre-formulated topical solution. Reconstitute under sterile conditions. Aliquot or refrigerate for multi-dose use. For research use only.
