🧬 Tirzepatide + Retatrutide Stack: Unlocking Multi-Pathway Metabolic Optimisation
Composition: 20 mg Retatrutide + 40 mg Tirzepatide
Synonyms: LY3437943 (Retatrutide), LY3298176 (Tirzepatide)
CAS Numbers: 2758366-68-9 (Retatrutide), 2023788-19-2 (Tirzepatide)
Sequence: Proprietary dual-peptide blend
Molecular Weight: ~7.9 kDa (combined)
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. This compound is not approved for human or veterinary use..
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Description:
ShredPept Duo is a synergistic peptide formulation combining Retatrutide and Tirzepatide to investigate multi-axis incretin and glucagon receptor pathways. Retatrutide engages GLP-1, GIP, and GCGR receptors, while Tirzepatide targets GLP-1 and GIP with high affinity. Together, they offer enhanced metabolic modulation, appetite suppression, and fat oxidation. Engineered for extended half-life and potent receptor engagement, ShredPept Duo is a leading research scaffold in the study of advanced body composition and energy homeostasis.
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⚙️ Mechanism of Action:
ShredPept Duo activates three key metabolic receptors, initiating a coordinated cascade of physiological effects:
• GLP-1R Activation: Enhances insulin secretion, suppresses glucagon, delays gastric emptying
• GIPR Activation: Amplifies insulinotropic effects, supports lipid metabolism and energy balance
• GCGR Activation (via Retatrutide): Increases energy expenditure, promotes lipolysis, supports weight reduction
This triple-receptor engagement mimics and amplifies endogenous hormonal pathways, making ShredPept Duo a unique scaffold for studying aggressive metabolic reprogramming.
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📈 Research Applications:
ShredPept Duo is of significant interest in preclinical models focused on:
• Obesity and accelerated fat loss
• Type 2 diabetes and glycaemic control
• Appetite suppression and satiety signalling
• Lipid metabolism and insulin sensitivity
Its extended duration of action and receptor synergy make it suitable for long-term metabolic studies.
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📌 Dosing Protocol for research applications
• Tirzepatide: 5000mcg/week
• Retatrutide: 2500mcg/week
• Administered to test subjects via a single subcutaneous injection
• Can be split into 2–3 injections/week for stable blood levels (take the standard dose and divide by the number of days you expect to administer for dosage quantities.
• Alternate-day dosing may be recommended for smoother GI tolerance and consistent receptor saturation.
🧬 ShredPept Duo – Triple Receptor Synergy Stack (GLP-1 + GIP + GCGR)
📦 Packaging & Handling:
• Supplied as a sterile-filtered lyophilized peptide ,reconstituted blend in a Disposable pen
• Reconstituted with 2.4ml Bacteriostatic water
• Store in the refrigerator to maintain integrity (2–8 °C)
SKU: TRZ40-RET20-RP-V1
