🧬 Retatrutide – Triple Receptor Agonist (GLP-1 + GIP + Glucagon)
Synonyms: LY3437943
CAS Number: 2768074-01-5
Sequence: C₂₈₄H₄₅₂N₇₈O₈₅
Molecular Weight: ~6,000 Da (approximate)
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. Not for human consumption.
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Description:
Retatrutide is a next-generation synthetic peptide designed as a tri-agonist targeting three key metabolic receptors: GLP-1R (glucagon-like peptide-1 receptor), GIPR (glucose-dependent insulinotropic polypeptide receptor), and GCGR (glucagon receptor). This multi-receptor engagement positions Retatrutide at the forefront of research into energy homeostasis, adiposity modulation, and glycemic regulation.
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⚙️ Mechanism of Action:
Retatrutide’s triple agonist profile initiates a coordinated metabolic response:
• GLP-1R Activation: Enhances insulin secretion, suppresses glucagon, delays gastric emptying
• GIPR Activation: Amplifies insulinotropic effects and supports lipid metabolism
• GCGR Activation: Promotes energy expenditure via hepatic and adipose tissue pathways
This integrated signaling cascade is under investigation for its potential to reduce caloric intake, increase thermogenesis, and improve insulin sensitivity in preclinical models.
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📈 Research Applications:
Retatrutide is being explored in metabolic research for its potential to:
• Modulate body weight and adiposity
• Improve glucose tolerance and insulin dynamics
• Influence lipid profiles and hepatic fat content
• Support multi-axis endocrine regulation
Its tri-receptor activity offers a unique scaffold for studying combinatorial incretin and glucagon signaling in metabolic disease models.
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📦 Packaging & Handling:
• Supplied as a sterile-filtered lyophilized peptide
• Store at –20°C in a desiccated environment
• Reconstitute with bacteriostatic water, acetic acid, or other suitable diluent
• store in a refrigerator once a reconstituted solution to maintain stability 2-8 °C
SKU: RET-20MG-VIAL
