🧬 Cagrilintide – Long-Acting Amylin & Calcitonin Receptor Agonist (DACRA)
Synonyms: AM833, NNC0174-0833
CAS Number: 2768074-01-5
Sequence: C₂₈₄H₄₃₀N₇₈O₈₄
Molecular Weight: ~5,800–6,000 Da (approximate)
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. Not for human consumption.
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Description:
Cagrilintide is a synthetic peptide analog of human amylin, engineered to act as a dual amylin and calcitonin receptor agonist (DACRA). It is structurally optimized for enhanced receptor binding, metabolic stability, and reduced fibrillogenicity. Cagrilintide is under active investigation for its role in appetite regulation, gastric motility, and glucagon suppression, making it a compelling candidate in the study of obesity, type 2 diabetes, and energy balance.
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⚙️ Mechanism of Action:
Cagrilintide exerts its effects through coordinated activation of:
• Amylin Receptors: Modulates postprandial glucagon secretion, slows gastric emptying, and enhances satiety signaling
• Calcitonin Receptors: Contributes to appetite suppression and may influence glucose and lipid metabolism
Its long-acting profile allows for sustained receptor engagement, supporting extended observation windows in metabolic research models.
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📈 Research Applications:
Cagrilintide is being explored in preclinical settings for its potential to:
• Reduce caloric intake and body weight
• Improve glycemic control and insulin sensitivity
• Enhance satiety signaling and gastric regulation
• Serve as a synergistic agent in combination with GLP-1 analogs (e.g., Semaglutide)
Its dual-receptor activity offers a unique platform for studying multi-hormonal modulation of metabolic pathways.
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📦 Packaging & Handling:
• Supplied as a sterile-filtered lyophilized peptide
• Store at –20°C in a dry, light-protected environment
• Reconstitute with bacteriostatic water, acetic acid, or other suitable diluent
• store in the refrigerator once a reconstituted solution to preserve bioactivity 2-8 °C
SKU: CAG-10MG-VIAL
