🧬 Tesamorelin – Stabilized GHRH Analog for Endogenous GH Axis Modulation
Synonyms: Egrifta, TH9507, Tesamorelin Acetate
CAS Number: 218949-48-5
Sequence: C₂₂₁H₃₆₆N₇₂O₆₁S
Molecular Weight: ~5135 Da
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. Not for human consumption.
---
Description:
Tesamorelin is a synthetic 44-amino acid peptide analog of growth hormone-releasing hormone (GHRH), engineered for enhanced stability and receptor affinity. It selectively binds to GHRH receptors (GHRHr) in the anterior pituitary, stimulating pulsatile release of endogenous growth hormone (GH). Unlike exogenous GH, Tesamorelin preserves physiological feedback loops, making it a valuable tool for studying GH axis modulation, lipid metabolism, and visceral adiposity.
---
⚙️ Mechanism of Action:
Tesamorelin activates the hypothalamic-pituitary-GH axis by:
• Binding to GHRH receptors in the pituitary
• Stimulating somatotrophs to release GH in a natural rhythm
• Elevating IGF-1 levels downstream, supporting anabolic and lipolytic effects
• Preserving negative feedback regulation, reducing risk of GH desensitization
This mechanism supports investigations into fat redistribution, muscle preservation, and neuroendocrine signaling.
---
📈 Research Applications:
Tesamorelin is under investigation in preclinical and in vitro models for:
• Visceral fat reduction and lipodystrophy modeling
• Cognitive function and neuroprotection
• Peripheral nerve regeneration
• Age-related GH decline and metabolic dysfunction
Its ability to restore youthful GH pulsatility without supraphysiologic exposure makes it ideal for longitudinal metabolic studies.
---
📦 Packaging & Handling:
• Supplied as a sterile-filtered lyophilized peptide
• Store at –20°C, protected from light and moisture
• Reconstitute with bacteriostatic water or appropriate diluent
• Store in the refrigerator once a reconstituted solution to preserve bioactivity 2-8°C
SKU: TES-10MG-VIAL
