🧬 5-Amino-1MQ – NNMT Inhibitor for Metabolic and NAD⁺ Pathway Research
Synonyms: 5-Amino-1-methylquinolinium, 5-Amino-1MQ
CAS Number: 14003-96-4
Chemical Formula: C₁₀H₁₁N₂⁺
Molecular Weight: ~159.21 g/mol
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. Not for human consumption.
---
Description:
5-Amino-1MQ is a small-molecule compound designed to selectively inhibit nicotinamide N-methyltransferase (NNMT), an enzyme implicated in adipose tissue metabolism, NAD⁺ salvage pathways, and cellular energy regulation. By targeting NNMT, 5-Amino-1MQ has emerged as a promising research scaffold for exploring fat oxidation, muscle preservation, and metabolic reprogramming in preclinical models.
---
⚙️ Mechanism of Action:
5-Amino-1MQ functions as a selective NNMT inhibitor, leading to:
• Increased NAD⁺ availability via reduced methylation of nicotinamide
• Activation of SIRT1, a longevity-associated deacetylase
• Enhanced AMPK signaling, promoting fatty acid oxidation and mitochondrial biogenesis
• Reduced lipogenesis and adipocyte hypertrophy
These pathways collectively support investigations into energy expenditure, insulin sensitivity, and body composition modulation A.
---
📈 Research Applications:
5-Amino-1MQ is under active investigation in models of:
• Obesity and diet-induced adiposity
• Type 2 diabetes and insulin resistance
• Muscle regeneration and sarcopenia
• NAD⁺ metabolism and cellular aging
• Cancer metabolism and NNMT overexpression
Its small-molecule structure allows for oral or injectable administration in animal studies, with favorable cellular permeability and bioavailability A.
---
📦 Packaging & Handling:
• Supplied as a sterile-filtered lyophilized powder
• Store at –20°C, protected from light and moisture
• Reconstitute with DMSO, ethanol, or appropriate solvent for in vitro or in vivo use
• Store on a refrigerator once in a reconstituted solution to maintain stability 2-8 °C
SKU: 1MQ-10MG-VIAL
