GHK-Cu – Technical Brief (Research-Use-Only)
1. Identity
GHK-Cu (Glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper peptide known for its skin regeneration, wound healing, and anti-aging properties. It plays a crucial role in tissue repair and cellular health.
2. Mechanism of Action
GHK-Cu works by:
- Stimulating collagen and elastin production: Enhances skin firmness and elasticity.
- Promoting wound healing: Accelerates tissue repair and reduces scarring.
- Acting as an antioxidant: Neutralizes reactive oxygen species (ROS) to protect cells.
- Regulating copper-dependent processes: Supports enzymatic functions in skin and hair health.
3. Uses
GHK-Cu is primarily researched for:
- Skin regeneration: Reduces wrinkles, improves skin clarity, and enhances elasticity.
- Wound healing: Accelerates recovery and minimizes scar formation.
- Hair growth: Stimulates follicle activity and may help with hair thinning.
- Anti-aging: Potential systemic benefits in reversing age-related cellular decline.
4. Dosage
Common research protocols include:
- Skin regeneration: 1–2% topical serum, applied once or twice daily.
- Wound healing: 1–10% solution, applied directly to affected areas.
- Hair growth: 0.01–100 nM concentration in topical formulations.
- Research applications: typically between 1000 - 2000mcg.
- Administered subcutaneously using an insulin syringe once daily.
5. Safety Profile
- Common side effects: Mild skin irritation, temporary redness.
- Precautions: Generally well-tolerated, but long-term effects require further study.
- No systemic toxicity: Unlike some peptides, GHK-Cu does not interfere with hormonal pathways.
6. Storage Guidelines
- Before mixing: Store the lyophilized powder in a refrigerator (2–8°C / 36–46°F), protected from light.
- After mixing: Keep refrigerated and use within 30–45 days.
- Room temperature storage: Can be kept at up to 30°C (86°F) for a maximum of 21 days, but should not be returned to refrigeration afterward.
- Do not freeze: Freezing reconstituted vials can degrade the peptide’s integrity.
7. Legality in the UK
GHK-Cu is available for research purposes but is not classified as a prescription medication. It is commonly found in cosmetic formulations and anti-aging products, but its use in medical treatments is not officially regulated by the MHRA (Medicines and Healthcare products Regulatory Agency).
