š§¬ GHK-Cu ā Copper-Binding Tripeptide for Regenerative & Anti-Aging Research
Synonyms: Glycyl-L-Histidyl-L-Lysine Copper Complex, Copper Tripeptide-1
CAS Number: 89030-95-5
Sequence: Gly-His-LysĀ·CuĀ²āŗ
Molecular Weight: ~403.9 Da (complexed form)
Form: Lyophilized powder
Purity: ā„98% (HPLC)
Research Use Only. Not for human consumption.
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Description:
GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine, histidine, and lysine, complexed with a divalent copper ion (CuĀ²āŗ). It is endogenously present in plasma, saliva, and urine, with levels declining significantly with age. GHK-Cu is under active investigation for its role in tissue remodeling, wound healing, angiogenesis, and anti-inflammatory signaling, making it a versatile scaffold in regenerative and dermatological research.
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āļø Mechanism of Action:
GHK-Cu exerts its biological effects through multiple converging pathways:
ā¢ Collagen & ECM Remodeling: Stimulates synthesis of collagen, elastin, glycosaminoglycans, and decorin
ā¢ Anti-Inflammatory Modulation: Downregulates pro-inflammatory cytokines (e.g., TNF-Ī±, IL-6)
ā¢ Angiogenesis Support: Provides bioavailable copper essential for vascular endothelial growth
ā¢ Wound Healing: Enhances fibroblast activity and promotes scarless tissue regeneration
ā¢ Neuroregeneration: Encourages axonal outgrowth and synaptic repair in neuronal models
ā¢ DNA Repair & Epigenetic Resetting: Shown to influence gene expression linked to cellular rejuvenation
Its ability to act as a tissue-specific signaling molecule makes it a compelling candidate in both cosmetic and therapeutic research domains.
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š Research Applications:
GHK-Cu is being explored in preclinical and in vitro models for:
ā¢ Skin regeneration and anti-aging
ā¢ Hair follicle stimulation and pigmentation
ā¢ Wound healing and scar reduction
ā¢ Neuroinflammation and nerve repair
ā¢ Osteogenesis and bone remodeling
ā¢ UV protection and photodamage mitigation
Its non-hormonal, non-immunogenic profile makes it suitable for long-term regenerative studies.
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š¦ Packaging & Handling:
ā¢ Supplied as a sterile-filtered lyophilized peptideāmetal complex
ā¢ Store at ā20Ā°C, protected from light and moisture
ā¢ Reconstitute with bacteriostatic water, saline, or appropriate buffer
ā¢ Store in the refrigerator once in a reconstituted solution to preserve stability 2-8 Ā°C
SKU: GHK-100MG-VIAL
