🧬 CJC-1295 (No DAC) – Modified GRF (1-29) for Pulsatile GH Release & Pituitary Axis Research
Synonyms: Modified GRF 1-29, CJC-1295 without DAC, Mod-GRF
CAS Number: 863288-34-0
Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Molecular Weight: ~3367.9 Da
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. Not for human consumption.
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Description:
CJC-1295 without DAC is a synthetic analog of growth hormone-releasing hormone (GHRH), specifically modified to enhance stability and receptor affinity while preserving natural pulsatile GH release. Unlike its DAC-bound counterpart, this version mimics the body’s endogenous GHRH kinetics, making it ideal for short-acting, time-sensitive protocols. It is often referred to as Modified GRF (1-29) and is commonly paired with GHRPs (e.g., Ipamorelin) to amplify pituitary output.
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⚙️ Mechanism of Action:
CJC-1295 (No DAC) binds to GHRH receptors on the anterior pituitary, triggering:
• Pulsatile growth hormone secretion aligned with circadian rhythm
• Upregulation of IGF-1 via hepatic stimulation
• Enhanced protein synthesis, lipolysis, and tissue repair
• Synergistic GH release when co-administered with GHRPs
Its short half-life (~30 minutes) allows for precise control over GH timing, ideal for studies requiring acute endocrine modulation.
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📈 Research Applications:
CJC-1295 without DAC is under investigation in preclinical models for:
• Growth hormone deficiency and pituitary axis mapping
• Muscle hypertrophy and recovery
• Fat metabolism and body composition modulation
• Sleep architecture and circadian rhythm studies
• Combination protocols with GHRP-2, GHRP-6, or Ipamorelin
Its non-hormonal, endocrine-supportive profile makes it a versatile scaffold for GH-axis exploration.
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🧪 Dosing & Handling (Preclinical):
• Typical dose: 100–200 mcg, 1–3x daily
• Timing: Administer on an empty stomach; avoid carbs pre/post injection
• Cycle: 4–8 weeks; often stacked with GHRPs
• Reconstitution: Use bacteriostatic water.
• Store in the refrigerator once a reconstituted solution to preserve integrity 2-8°C
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📦 Packaging & Storage:
Supplied as sterile-filtered lyophilized powder in 10mg vials. Reconstitute under sterile conditions. For research use only.