🧬 TB-500 – Synthetic Thymosin Beta-4 Fragment for Regeneration & Wound Healing Research
Synonyms: Thymosin Beta-4 Fragment, Timbetasin
CAS Number: 77591-33-4
Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
Molecular Weight: ~4963.4 Da
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. This compound is not approved for human or veterinary use.
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Description:
TB-500 is a synthetic 43-amino acid peptide fragment derived from Thymosin Beta-4 (Tβ4), a naturally occurring protein found in platelets, wound fluid, and various tissues. It is designed to mimic the regenerative properties of Tβ4, particularly its ability to modulate actin dynamics, promote angiogenesis, and accelerate tissue repair. TB-500 is widely studied for its role in muscle recovery, connective tissue regeneration, and vascular remodeling.
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⚙️ Mechanism of Action:
TB-500 regulates cellular actin, a key structural protein involved in cell migration and repair. It:
• Sequesters G-actin, preventing polymerization and enabling cytoskeletal reorganization
• Stimulates angiogenesis via Notch and VEGF signaling pathways
• Enhances stem cell recruitment and differentiation at injury sites
• Promotes collagen alignment and scar minimization
• Modulates inflammatory cytokines and supports immune cell migration
Its non-anabolic, non-hormonal profile makes it ideal for regenerative and anti-inflammatory research.
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📈 Research Applications:
TB-500 is under investigation in preclinical models for:
• Muscle, tendon, and ligament repair
• Cardiac tissue regeneration post-infarction
• Wound healing and scar reduction
• Hair follicle stimulation and dermal remodeling
• Endothelial function and neovascularization
• Dry eye and corneal healing protocols
Studies show improved collagen maturity, vascular density, and functional recovery in injury models.
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🧪 Dosing & Handling (Preclinical):
• Typical dose: 2–5 mg twice weekly for general use; 5–10 mg for acute injury
• Cycle: 4–6 weeks, followed by maintenance dosing
• Reconstitution: Use bacteriostatic water; swirl gently to dissolve
• Administration: Subcutaneous or intramuscular injection
• Store in the refrigerator once a reconstituted solution to preserve integrity 2-8°C
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📦 Packaging & Storage:
Supplied as sterile-filtered lyophilized powder in 10mg vials. Reconstitute under sterile conditions. Aliquot and refrigerate for multi-dose use. For research use only.
