🧬 AOD-9604 – Modified hGH Fragment (176–191) for Lipolytic Research
Synonyms: Anti-Obesity Drug 9604, hGH Frag 176–191, Tyr-hGH(176–191)
CAS Number: 221231-10-3
Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Molecular Weight: ~1,814 Da
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. This compound is not approved for human or veterinary use..
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Description:
AOD-9604 is a synthetic peptide fragment derived from the C-terminal region (176–191) of human growth hormone (hGH), specifically engineered to retain the lipolytic (fat-burning) properties of hGH without its anabolic or diabetogenic effects. By isolating this bioactive domain and adding a tyrosine residue at the N-terminus, AOD-9604 exhibits enhanced metabolic stability and receptor selectivity, making it a compelling candidate in adipose tissue metabolism research.
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⚙️ Mechanism of Action:
AOD-9604 is believed to exert its effects through:
• Stimulation of lipolysis: Promotes breakdown of stored triglycerides in adipocytes
• Inhibition of lipogenesis: Reduces conversion of non-fat substrates into fat
• Selective action on adipose tissue: Minimal impact on muscle growth or IGF-1 levels
Unlike full-length hGH, AOD-9604 does not stimulate insulin resistance or linear growth, making it a focused tool for studying fat metabolism without systemic endocrine disruption A.
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📈 Research Applications:
AOD-9604 is under investigation in preclinical models for:
• Obesity and adiposity modulation
• Targeted fat reduction protocols
• Metabolic syndrome and lipid regulation
• Synergistic use with GLP-1 analogs (e.g., Semaglutide) in combination studies
Its unique mechanism makes it suitable for localized fat metabolism studies and non-anabolic metabolic modulation.
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📦 Packaging & Handling:
• Supplied as a sterile-filtered lyophilized peptide
• Store at –20°C in a desiccated, light-protected environment
• Reconstitute with bacteriostatic water or acetic acid as appropriate
• store in the refrigerator once a reconstituted solution to preserve bioactivity 2-8°C
SKU: AOD-5MG-VIAL
