🧬 Tirzepatide – Dual Incretin Receptor Agonist (GLP-1 + GIP)
Synonyms: LY3298176
CAS Number: 2023788-19-2
Sequence: C₂₂₅H₃₄₃N₆₅O₆₈
Molecular Weight: 4817.48 g/mol
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. Not for human consumption.
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Description:
Tirzepatide is a synthetic 39-amino acid peptide analog engineered for the investigation of dual incretin receptor pathways, exhibiting high affinity toward both GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptors. Designed for enhanced metabolic stability, extended half-life, and potent receptor engagement, Tirzepatide is a prominent research candidate in the study of glucose regulation, satiety signaling, and energy homeostasis.
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⚙️ Mechanism of Action:
Tirzepatide functions as a dual agonist of the GLP-1 and GIP receptors, initiating a multifaceted cascade of metabolic activities:
• GLP-1R Activation: Enhances glucose-stimulated insulin secretion, suppresses glucagon, delays gastric emptying.
• GIPR Activation: Synergizes insulinotropic action and contributes to lipid metabolism and energy balance.
• Integrated Signaling: Modulates hypothalamic appetite pathways and supports insulin sensitivity in peripheral tissues.
This dual-receptor engagement mimics and amplifies endogenous incretin effects, making it a unique scaffold for studying multi-axis metabolic modulation.
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📈 Research Applications:
Tirzepatide is of significant interest in preclinical models focused on:
• Obesity and appetite suppression
• Type 2 diabetes and glycemic control
• Insulin resistance and beta-cell preservation
• Lipid metabolism and cardiovascular markers
Its extended duration of action and receptor selectivity make it suitable for long-term observational protocols.
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📦 Packaging & Handling:
• Supplied as a sterile-filtered lyophilized peptide
• Recommended storage: –20°C (dry conditions)
• Reconstitute using bacteriostatic water, acetic acid, or appropriate research-grade diluent
• store in the refrigerator once a reconstituted solution to maintain integrity 2-8 °C
SKU: TRZ-40MG-VIAL
