🧬 Epithalon – Telomerase-Activating Tetrapeptide for Cellular Longevity & Circadian Regulation
Synonyms: Epitalon, AEDG peptide, Epithalone
CAS Number: 307297-39-8
Sequence: Ala-Glu-Asp-Gly
Molecular Weight: ~390.35 Da
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Research Use Only. Not for human consumption.
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Description:
Epithalon is a synthetic tetrapeptide bioregulator derived from epithalamin, a natural extract of the pineal gland. It was developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. Epithalon is designed to stimulate telomerase activity, thereby promoting telomere elongation, genomic stability, and cellular longevity. It also modulates melatonin synthesis, making it a dual-action scaffold for anti-aging and circadian rhythm optimization.
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⚙️ Mechanism of Action:
Epithalon activates telomerase in somatic cells, delaying telomere shortening and extending the replicative lifespan of cells. It also:
• Enhances pineal gland function, increasing melatonin output
• Normalizes cortisol rhythms and supports sleep architecture
• Reduces oxidative stress via upregulation of antioxidant enzymes
• Modulates gene expression linked to aging and immune resilience
• Supports DNA repair and chromatin remodeling under stress conditions
Its non-hormonal, non-anabolic profile makes it ideal for long-term studies in aging and neuroendocrine regulation.
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📈 Research Applications:
Epithalon is under investigation in preclinical and clinical models for:
• Telomere biology and cellular senescence
• Sleep enhancement and circadian rhythm regulation
• Immune system rejuvenation and thymic support
• Neurodegenerative disease prevention
• Oncostatic effects in hormone-sensitive cancers
• Cardiovascular aging and metabolic resilience
Studies have shown up to 25–30% lifespan extension in animal models, with improved physiological function and reduced age-related pathology A.
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🧪 Dosing & Handling (Preclinical):
• Typical dose: 2–10 mg/day
• Cycle: 10–20 days, repeated 2–3x/year
• Route: Subcutaneous injection (bedtime preferred)
• Reconstitution: Use bacteriostatic water or acetic acid
• Store in the refrigerator once a reconstituted solution to preserve integrity 2-8°C
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📦 Packaging & Storage:
Supplied as sterile-filtered lyophilized powder in 50mg vials. Reconstitute under sterile conditions. Aliquot and freeze for multi-dose use. For research use only.
