š§¬ NADāŗ ā Cellular Coenzyme for Energy Metabolism, DNA Repair & Longevity Research
Synonyms: Nicotinamide Adenine Dinucleotide (oxidized form)
CAS Number: 53-84-9
Molecular Formula: CāāHāāNāOāāPā
Molecular Weight: ~663.43 g/mol
Form: Lyophilized powder or injectable solution
Purity: ā„98% (HPLC)
Research Use Only. This compound is not approved for human or veterinary use.
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Description:
NADāŗ is a ubiquitous redox coenzyme found in all living cells, essential for electron transport, ATP production, and cellular signaling. It serves as a substrate for sirtuins, PARPs, and CD38, regulating processes such as DNA repair, chromatin remodeling, and circadian rhythm. NADāŗ levels decline with age, contributing to metabolic dysfunction, neurodegeneration, and immunosenescence. Supplementation via NADāŗ or its precursors (e.g., NMN, NR) is under active investigation for anti-aging, mitochondrial support, and cognitive enhancement.
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āļø Mechanism of Action:
NADāŗ participates in:
ā¢ Redox reactions: Transfers electrons in glycolysis, TCA cycle, and oxidative phosphorylation
ā¢ Sirtuin activation: Regulates gene expression, metabolism, and chromosomal stability
ā¢ PARP-mediated DNA repair: Facilitates genomic integrity under oxidative stress
ā¢ CD38 signaling: Modulates calcium homeostasis and immune cell function
ā¢ Circadian rhythm regulation: Interfaces with CLOCK/BMAL1 transcriptional loops
Its depletion is linked to aging hallmarks, while restoration may reverse age-associated pathologies.
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š Research Applications:
NADāŗ is under investigation in preclinical and clinical models for:
ā¢ Longevity and age reversal
ā¢ Mitochondrial dysfunction and fatigue
ā¢ Neurodegenerative diseases (e.g., Alzheimerās, Parkinsonās)
ā¢ Metabolic disorders (e.g., obesity, insulin resistance)
ā¢ Cardiovascular health and endothelial function
ā¢ Muscle regeneration and exercise capacity
Studies show NADāŗ restoration improves VOā max, insulin sensitivity, and cognitive performance, with potential lifespan extension in animal models.
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š§Ŗ Dosing & Handling (Preclinical):
ā¢ Typical dose: 250ā1000 mg/day (oral, IV, or injectable)
ā¢ Precursors: NMN, NR, niacinamide (oral or transdermal)
ā¢ Half-life: Rapid turnover; sustained elevation requires repeated dosing or precursor cycling
ā¢ Administration: IV infusion, SubQ injection, or oral precursors depending on protocol
ā¢ Cycle: 4ā12 weeks depending on study goals
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š¦ Packaging & Storage:
Supplied as lyophilized powder in larger brown 30ml vials.
Store in the refrigerator once a reconstituted solution to preserve integrity 2-8Ā°C, protected from light and moisture.
Reconstitute with bacteriostatic water or saline. Use aseptic technique.
