Melanotan 1, also known as afamelanotide, is a synthetic analogue of the alpha-melanocyte-stimulating hormone (α-MSH). It is primarily researched for its ability to stimulate melanin production, offering potential benefits in skin pigmentation, UV protection, and certain dermatological conditions.
Mechanism of Action
Melanotan 1 works by:
• Binding to melanocortin 1 receptors (MC1R): Stimulates melanogenesis, the process by which melanin is produced in the skin.
• Enhancing UV protection: Increased melanin acts as a natural barrier against ultraviolet radiation.
• Modulating inflammation: May have anti-inflammatory and antioxidant effects through melanocortin pathways.
Uses
Melanotan 1 is primarily researched for:
• Skin pigmentation: Promotes a tan-like effect without excessive sun exposure.
• Photoprotection: Used in conditions like erythropoietic protoporphyria (EPP) to reduce UV sensitivity.
• Cosmetic tanning: Popular in off-label use for aesthetic skin darkening.
• Potential metabolic and neuroprotective effects: Under investigation in early-stage studies.
Dosage
Research protocols vary, but typical dosing includes:
• Initial dose: 0.25–0.5mg subcutaneously per day.
• Titration: Gradually increased to 1mg or more depending on response and tolerance.
• Maintenance: 1–2 doses per week once desired pigmentation is achieved.
• Administration: Subcutaneous injection using an insulin syringe.
Safety Profile
• Common side effects: Nausea, facial flushing, appetite suppression, and darkening of moles or freckles.
• Precautions: Not recommended for individuals with a history of melanoma or atypical skin lesions.
• Long-term effects: Still under investigation; caution advised due to limited human data.
Storage Guidelines
• Before mixing: Store lyophilized powder in a refrigerator (2–8°C / 36–46°F), protected from light.
• After mixing: Keep refrigerated and use within 30–45 days.
• Room temperature storage: Can be kept at up to 30°C (86°F) for a maximum of 21 days, but should not be returned to refrigeration afterward.
• Do not freeze: Freezing may degrade the peptide’s structure.
Legality in the UK
Melanotan 1 is not approved for medical or cosmetic use in the UK. It is classified as an unlicensed medicine, and the MHRA (Medicines and Healthcare products Regulatory Agency) prohibits its sale, supply, or advertising for human use A. Despite this, it is sometimes found in gyms or online, prompting public health warnings due to safety concerns.
