🧬 GHRP-6 Acetate – Hexapeptide Secretagogue for GH Pulsatility & Recovery Research
Synonyms: Growth Hormone Releasing Peptide-6, GHRP-6
CAS Number: 87616-84-0
Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
Molecular Weight: ~873.0 Da
Form: Lyophilized acetate salt
Purity: ≥98% (HPLC)
Research Use Only. This compound is not approved for human or veterinary use..
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Description:
GHRP-6 Acetate is a synthetic hexapeptide that acts as a growth hormone secretagogue, binding to the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary. It triggers pulsatile GH release, bypassing somatostatin inhibition and mimicking endogenous ghrelin signaling. The acetate form offers enhanced solubility, making it ideal for subcutaneous administration in short-acting protocols. GHRP-6 is often paired with GHRH analogs (e.g., CJC-1295 No DAC) to amplify pituitary output.
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⚙️ Mechanism of Action:
GHRP-6 binds to GHS-R1a, initiating a cascade that:
• Stimulates growth hormone release from somatotrophs
• Suppresses somatostatin, the GH-inhibiting hormone
• Elevates IGF-1 via hepatic stimulation
• Enhances protein synthesis, lipolysis, and tissue repair
• Activates appetite signaling via hypothalamic pathways
Its non-hormonal, receptor-driven mechanism makes it ideal for endocrine axis mapping and GH optimization studies.
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📈 Research Applications:
GHRP-6 Acetate is under investigation in preclinical models for:
• GH deficiency and pituitary axis modulation
• Muscle hypertrophy and recovery
• Fat metabolism and body composition
• Cardiac remodeling and post-infarction repair
• Appetite regulation and metabolic signaling
• Combination protocols with GHRH analogs or IGF-1 LR3
Studies show enhanced GH pulsatility, improved cardiac output, and accelerated recovery in injury models.
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🧪 Dosing & Handling (Preclinical):
• Typical dose: 100–300 mcg, 1–3x daily
• Timing: Administer fasted; avoid carbs pre/post injection
• Cycle: 4–8 weeks; often stacked with CJC-1295 No DAC
• Reconstitution: Use bacteriostatic water
• Store in the refrigerator once a reconstituted solution to preserve integrity 2-8°C
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📦 Packaging & Storage:
Supplied as sterile-filtered lyophilized acetate salt in 10mg vials. Reconstitute under sterile conditions. For research use only.
