Losacar-H is a combination antihypertensive medication that contains losartan and hydrochlorothiazide. It is primarily used to manage high blood pressure (hypertension) and is manufactured by Zydus Cadila. The packaging typically consists of 30 tablets.
Key Uses
- Hypertension Management: Losacar-H is effective in lowering high blood pressure, particularly when treatment with losartan alone is insufficient.
- Stroke Prevention: It can help reduce the risk of stroke in patients with high blood pressure and left ventricular hypertrophy (enlargement of the heart).
Mechanism of Action
- Losartan: An angiotensin II receptor blocker (ARB) that relaxes blood vessels by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict.
- Hydrochlorothiazide: A thiazide diuretic that increases urine production, helping the body eliminate excess salt and water, which further helps lower blood pressure.
Dosage and Administration
- Recommended Dosage: The typical starting dose is usually 50 mg of losartan and 12.5 mg of hydrochlorothiazide, taken once daily. Dosage may be adjusted based on individual response and blood pressure levels.
- Administration Instructions: Take the tablet with a full glass of water, with or without food. Do not crush or chew the tablet.
Side Effects
Common side effects may include:
- Nausea
- Diarrhea
- Abdominal pain
- Dizziness or lightheadedness
- Fatigue
Serious side effects can include:
- Severe allergic reactions (e.g., rash, swelling)
- Low blood pressure (hypotension)
- Kidney damage or changes in kidney function
- Electrolyte imbalances (e.g., low potassium)
Precautions
- Contraindications: Not recommended for individuals with known allergies to losartan, hydrochlorothiazide, or sulfonamide derivatives. Caution is advised in patients with severe liver or kidney issues.
- Pregnancy and Breastfeeding: Should not be used during pregnancy, especially in the second and third trimesters, due to potential harm to the fetus. Consult a healthcare provider if breastfeeding.
- Drug Interactions: Inform your doctor about all medications you are taking, as Losacar-H may interact with other antihypertensives, diuretics, or medications affecting kidney function.
