Erythromycin 250mg Tablets are an antibiotic medication used to treat a variety of bacterial infections. Erythromycin belongs to the macrolide class of antibiotics and is effective against many Gram-positive bacteria and certain Gram-negative bacteria.
Key Features
- Active Ingredient: Each tablet contains 250 mg of Erythromycin.
- Formulation: Typically available in a blister pack containing 10 tablets.
Indications
Erythromycin is indicated for the treatment of:
- Respiratory Tract Infections: Such as pneumonia, bronchitis, and infections caused by Mycoplasma pneumoniae.
- Skin Infections: Including conditions like impetigo and erythrasma.
- Gastrointestinal Infections: Effective against certain types of bacterial gastroenteritis.
- Sexually Transmitted Infections: Such as chlamydia and gonorrhea.
- Prevention of Rheumatic Fever: Used to prevent recurrent rheumatic fever in susceptible individuals.
Mechanism of Action
Erythromycin works by inhibiting bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, preventing the translation process necessary for bacterial growth and reproduction.
Dosage and Administration
- Recommended Dosage:
- For adults: The typical dosage is 250 mg taken four times daily, or 500 mg taken twice daily, depending on the severity of the infection.
- For children, dosages are usually calculated based on body weight (generally around 30 to 50 mg/kg/day in divided doses).
- Administration Instructions:
- Erythromycin should be taken on an empty stomach, preferably one hour before or two hours after meals, to enhance absorption.
- Swallow the tablets whole with a glass of water; do not crush or chew them.
Side Effects
Common side effects may include:
- Gastrointestinal upset such as nausea, vomiting, diarrhea, and abdominal cramps.
- Allergic reactions which may manifest as rash or itching.
Serious side effects can include:
- Liver problems (e.g., jaundice, dark urine).
- Severe diarrhea that may be watery or bloody (indicative of Clostridium difficile infection).
- Hearing loss, especially with high doses or prolonged use.
If any severe reactions occur, discontinue use immediately and seek medical attention.
Precautions
- Contraindications: Erythromycin should not be used in individuals with known hypersensitivity to erythromycin or other macrolide antibiotics.
- Caution in Special Populations: Use with caution in patients with liver disease or those taking medications that can interact with erythromycin (e.g., warfarin, digoxin).
- Pregnancy and Breastfeeding: Generally considered safe but consult a healthcare provider before use.
Interactions
Erythromycin may interact with several medications, including:
- Anticoagulants (like warfarin), which may increase bleeding risk.
- Other drugs that prolong the QT interval (such as certain antiarrhythmics) can lead to serious heart rhythm problems.
