Duo-Cotecxin is an antimalarial medication used to treat uncomplicated malaria caused by Plasmodium falciparum and Plasmodium vivax. It contains two active ingredients: Dihydroartemisinin and Piperaquine phosphate, which work together to effectively combat malaria, particularly in cases where resistance to other antimalarials is present.
Key Features
- Active Ingredients:
- Dihydroartemisinin: 40 mg per tablet
- Piperaquine phosphate: 320 mg per tablet
- Formulation: Each pack typically contains 9 tablets, designed for a complete treatment course.
Indications
Duo-Cotecxin is indicated for:
- Treatment of uncomplicated malaria, especially in cases of resistance to other antimalarial drugs.
- It is effective against both falciparum and vivax malaria.
Mechanism of Action
- Dihydroartemisinin acts quickly to kill the malaria parasites in the bloodstream.
- Piperaquine phosphate has a longer half-life, providing prolonged protection against malaria by remaining active in the body for several days after the initial dose.
Dosage and Administration
- Recommended Dosage: The typical dosing regimen involves taking one tablet daily for three consecutive days.
- Administration Instructions:
- Swallow the tablets whole with a glass of water after a meal.
- For young children, tablets can be crushed and mixed with water for easier administration.
Side Effects
Common side effects may include:
- Nausea and vomiting
- Abdominal pain
- Dizziness or headache
Serious side effects are rare but can include:
- Allergic reactions (e.g., rash, swelling)
- Cardiac issues such as QT prolongation (a heart rhythm condition)
If any severe reactions occur, discontinue use immediately and seek medical attention.
Precautions
- Contraindications: Avoid use in individuals with known hypersensitivity to Dihydroartemisinin or Piperaquine. It should not be used in patients with severe cardiac disorders or those taking medications that prolong the QT interval.
- Caution Required: Use with caution in elderly patients or those with renal or hepatic impairment. Regular monitoring may be necessary.
