Diclo Denk 100mg Suppositories, which contain Diclofenac, can interact with a variety of medications, potentially increasing the risk of side effects or altering the effectiveness of treatments. Here are key points regarding known interactions:
Major Drug Interactions
1. Other NSAIDs: Combining Diclofenac with other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, or aspirin can increase the risk of gastrointestinal bleeding and ulcers. It is generally advised to avoid using multiple NSAIDs simultaneously unless directed by a healthcare provider.
2. Anticoagulants: Diclofenac may enhance the effects of blood thinners like warfarin, increasing the risk of bleeding. Close monitoring is necessary if these medications are used together.
3. Antibiotics: Certain antibiotics (e.g., ciprofloxacin) may interact with Diclofenac, affecting kidney function and increasing the risk of side effects.
4. Diuretics: Medications that help remove excess fluid from the body (e.g., furosemide) may have reduced effectiveness when taken with Diclofenac due to potential kidney impairment.
5. Corticosteroids: Concurrent use with corticosteroids (e.g., prednisone) can increase the risk of gastrointestinal side effects.
6. Lithium: Diclofenac can increase lithium levels in the body, leading to toxicity; monitoring is recommended.
7. Methotrexate: The combination may increase methotrexate levels, raising the risk of toxicity.
Moderate Drug Interactions
- ACE Inhibitors and Angiotensin II Receptor Blockers: Drugs like lisinopril and losartan may have reduced effectiveness when taken with Diclofenac due to its effects on renal function.
- SSRIs: Selective serotonin reuptake inhibitors (e.g., sertraline) may increase bleeding risk when taken with Diclofenac.
Alcohol and Food Interactions
- Alcohol consumption should be minimized while taking Diclofenac, as it can increase the risk of gastrointestinal irritation and bleeding.
Disease Interactions
Diclofenac also has interactions with various health conditions, including:
- Gastrointestinal Disorders: Patients with a history of peptic ulcers or gastrointestinal bleeding should use Diclofenac cautiously.
- Kidney Disease: Individuals with renal impairment may experience worsened kidney function when taking this medication.
- Heart Conditions: Caution is advised in patients with heart failure or hypertension due to potential fluid retention and increased blood pressure.
