Carvedi Denk is a brand of carvedilol, a medication classified as a non-selective beta-blocker and alpha-1 blocker. It is primarily used to manage hypertension (high blood pressure), heart failure, and to improve heart function after a heart attack.
Key Uses
- Hypertension: Effective in lowering blood pressure, reducing the risk of stroke and heart attacks.
- Heart Failure: Helps improve symptoms and increase survival rates in patients with heart failure.
- Post-Myocardial Infarction: Used to enhance heart function in patients who have experienced a heart attack.
Mechanism of Action
Carvedilol works by:
- Blocking Beta Receptors: Reduces heart rate and myocardial contractility, which lowers cardiac output.
- Blocking Alpha-1 Receptors: Causes vasodilation (widening of blood vessels), which further decreases blood pressure.
Dosage and Administration
- Initial Dosage: The typical starting dose for hypertension is 12.5 mg once daily for the first two days. After this period, the dosage may be increased to 25 mg once daily based on the patient's response.
- Heart Failure: The starting dose is usually lower (3.125 mg twice daily), gradually increased based on tolerance and response.
- Administration: It is recommended to take carvedilol with food to reduce the risk of orthostatic hypotension (a drop in blood pressure upon standing).
Side Effects
Common side effects may include:
- Dizziness or lightheadedness
- Fatigue
- Nausea
- Diarrhea
- Bradycardia (slow heart rate)
Serious side effects can include severe allergic reactions, liver dysfunction, and worsening heart failure symptoms.
Warnings and Precautions
- Contraindications: Not suitable for individuals with known hypersensitivity to carvedilol or those with severe liver impairment.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if pregnant or breastfeeding.
- Abrupt Discontinuation: Do not stop taking carvedilol suddenly; this can lead to rebound hypertension or exacerbation of angina.
Storage
Store Carvedi Denk tablets at room temperature (below 25°C), away from moisture and direct sunlight. Keep out of reach of children.
