Clavulin is a combination antibiotic that contains amoxicillin and clavulanic acid. Each tablet of Clavulin 625mg contains 500 mg of amoxicillin (as amoxicillin trihydrate) and 125 mg of clavulanic acid (as potassium clavulanate). The product is typically packaged in a box containing 14 tablets.
Key Uses
Clavulin is indicated for the treatment of various bacterial infections, including:
- Respiratory Tract Infections: Such as pneumonia and bronchitis.
- Ear Infections: Including otitis media.
- Sinus Infections: Effective for acute bacterial sinusitis.
- Urinary Tract Infections: Treats infections like cystitis and pyelonephritis.
- Skin and Soft Tissue Infections: Such as cellulitis and abscesses.
Mechanism of Action
- Amoxicillin: A penicillin-type antibiotic that works by inhibiting bacterial cell wall synthesis, leading to cell death.
- Clavulanic Acid: A beta-lactamase inhibitor that protects amoxicillin from degradation by certain bacteria that produce beta-lactamase enzymes. This combination enhances the effectiveness of amoxicillin against resistant bacterial strains.
Dosage and Administration
- Adults and Children (over 12 years): The usual dosage for mild to moderate infections is typically 1 tablet every 12 hours. For severe infections, the dosage may be increased as directed by a healthcare provider.
- Children under 12 years: Not recommended for use without consulting a healthcare provider; pediatric formulations are available.
Clavulin tablets should be taken with a full glass of water, preferably at the start of a meal to enhance absorption.
Side Effects
Common side effects may include:
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Skin rash
Serious side effects can include:
- Severe allergic reactions (anaphylaxis)
- Liver dysfunction (elevated liver enzymes)
- Clostridium difficile-associated diarrhea
Warnings and Precautions
- Contraindications: Not suitable for individuals with known hypersensitivity to amoxicillin, clavulanic acid, or other beta-lactam antibiotics.
- Caution in Specific Populations: Use cautiously in patients with liver disease or those with a history of antibiotic-associated colitis.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if pregnant or breastfeeding.
Storage
Store Clavulin tablets at room temperature (below 25°C), away from moisture and direct sunlight. Keep out of reach of children.
