Amitriptyline is a tricyclic antidepressant primarily used for the treatment of major depressive disorder. It can also be effective in managing neuropathic pain, chronic tension-type headaches, and migraines. The 25 mg formulation is commonly prescribed for its therapeutic effects on mood and pain relief.
Dosage Form:
- Strength: 25 mg per tablet
- Packaging: Typically available in packs of 100 tablets (10 x 10).
Indications
Amitriptyline is indicated for:
- Major Depressive Disorder: Alleviates symptoms of depression.
- Neuropathic Pain: Provides relief from nerve pain conditions.
- Chronic Tension-Type Headache (CTTH): Used as a prophylactic treatment.
- Migraine Prevention: Helps reduce the frequency of migraine attacks.
Dosage
The recommended dosage varies based on the condition being treated:
- For Depression:
- Initial dose: 25 mg to 50 mg daily, often divided into two doses.
- Maintenance dose: Adjusted based on response, typically ranging from 100 mg to 150 mg daily.
- For Neuropathic Pain or Migraine Prevention:
- Starting doses may be lower (10 mg to 25 mg) at bedtime, with gradual increases as tolerated.
Warnings and Precautions
- Pregnant Women: Should use only if clearly needed; consult a healthcare provider before use.
- Elderly Patients: May require lower starting doses due to increased sensitivity.
- Patients with Pre-existing Conditions: Those with cardiovascular disease should use caution.
Drug Interactions
Amitriptyline may interact with other medications, particularly:
- Monoamine Oxidase Inhibitors (MAOIs): Concurrent use can lead to serious side effects.
- Other Antidepressants: Increased risk of serotonin syndrome when combined with SSRIs or SNRIs.
