Augmentin 457 mg/5 ml is a combination antibiotic that contains amoxicillin and clavulanic acid. This formulation is designed for oral suspension and is effective against a variety of bacterial infections. Amoxicillin works by inhibiting bacterial cell wall synthesis, while clavulanic acid protects amoxicillin from degradation by beta-lactamase-producing bacteria.
Composition
- Each 5 ml of the reconstituted suspension contains:
- Amoxicillin: 400 mg (as amoxicillin trihydrate)
- Clavulanic Acid: 57 mg (as potassium clavulanate)
Indications
Augmentin is indicated for the treatment of:
- Acute Bacterial Sinusitis
- Acute Otitis Media
- Exacerbations of Chronic Bronchitis
- Community-Acquired Pneumonia
- Cystitis and Pyelonephritis
- Skin and Soft Tissue Infections: Including animal bites and severe dental abscesses.
- Bone and Joint Infections: Such as osteomyelitis.
Dosage
- The dosing for Augmentin suspension is generally based on the severity of the infection and the patient's weight.
- For children, the typical dosage is calculated based on body weight, often expressed in mg/kg/day, divided into two or three doses.
- Adults may be prescribed a standard dose of 875 mg/125 mg every 12 hours or 500 mg/125 mg every 8 hours, depending on the infection's severity.
Administration
- How to Use: Shake the bottle well before each dose. Use a proper measuring device to ensure accurate dosing.
- It can be taken with or without food, but taking it at the start of a meal may enhance absorption and reduce gastrointestinal side effects.
Common Side Effects
Possible side effects may include:
- Diarrhea
- Nausea
- Vomiting
- Stomach pain
- Rash or itching
Serious side effects are rare but can include:
- Severe allergic reactions (e.g., hives, difficulty breathing)
- Liver problems (e.g., jaundice)
- Clostridioides difficile infection leading to severe diarrhea
Warnings and Precautions
- Contraindications: Not suitable for individuals with a known allergy to penicillin or cephalosporins, or those with a history of liver dysfunction related to Augmentin.
- Liver Function: Use cautiously in patients with liver impairment; regular monitoring may be necessary.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if you are pregnant or breastfeeding.
Drug Interactions
Inform your healthcare provider about all medications you are taking, especially:
- Other antibiotics
- Anticoagulants (may enhance the effect of blood thinners)
Storage
Store Augmentin suspension in a cool, dry place away from direct sunlight. After reconstitution, it should be refrigerated (2°C to 8°C) and used within 7 days. Do not freeze.
