Augmentin 375 mg is a combination antibiotic that contains amoxicillin and clavulanic acid. It is effective against a wide range of bacterial infections due to its dual action: amoxicillin works by inhibiting bacterial cell wall synthesis, while clavulanic acid protects amoxicillin from degradation by beta-lactamase enzymes produced by resistant bacteria.
Composition
Each tablet contains:
- Amoxicillin: 250 mg (as amoxicillin trihydrate)
- Clavulanic Acid: 125 mg (as potassium clavulanate)
Indications
Augmentin 375 mg is indicated for the treatment of various infections, including:
- Respiratory Tract Infections: Such as sinusitis, pneumonia, and bronchitis.
- Ear Infections: Otitis media.
- Skin and Soft Tissue Infections: Including cellulitis and animal bites.
- Urinary Tract Infections: Such as cystitis and pyelonephritis.
- Dental Infections: Severe dental abscesses with spreading cellulitis.
Dosage
- Adults and Children Over 40 kg: The usual recommended dose is 1 tablet (375 mg) every 8 hours or 1 tablet every 12 hours, depending on the severity of the infection.
- Children Under 40 kg: Dosing is based on body weight and should be determined by a healthcare provider.
Administration
- How to Use: Augmentin tablets should be taken orally with a full glass of water. It is recommended to take the medication with food to minimize gastrointestinal side effects.
- Missed Dose: If a dose is missed, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Common Side Effects
Possible side effects may include:
- Diarrhea
- Nausea
- Vomiting
- Stomach pain
- Rash or itching
Serious side effects are rare but can include:
- Severe allergic reactions (e.g., hives, difficulty breathing)
- Liver problems (e.g., jaundice, dark urine)
- Clostridioides difficile infection (C. diff), which can cause severe diarrhea
Warnings and Precautions
- Contraindications: Not suitable for individuals with a known allergy to penicillin or cephalosporins, or those who have experienced jaundice or hepatic dysfunction associated with Augmentin in the past.
- Liver Function: Use with caution in patients with liver impairment; monitor liver function during treatment.
- Pregnancy and Breastfeeding: Consult your healthcare provider before use if you are pregnant or breastfeeding.
Drug Interactions
Inform your healthcare provider about all medications you are taking, especially:
- Other antibiotics or anticoagulants
- Medications that affect liver enzymes
Storage
Store Augmentin tablets at room temperature (15° to 30°C), away from moisture and direct sunlight. Keep out of reach of children.
