Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used primarily for the relief of pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It acts by inhibiting the cyclooxygenase (COX) enzymes, leading to decreased production of prostaglandins, which are responsible for pain and inflammation.
Dosage
The recommended dosage for adults is generally:
- 200 mg daily, taken as two 100 mg doses (one in the morning and one in the evening), preferably after meals to minimize gastrointestinal side effects.
Warnings and Precautions
- Elderly Patients: Increased risk of renal impairment and gastrointestinal bleeding. Caution is advised due to potential age-related organ function decline.
- Pregnant Women: Should avoid use during pregnancy, particularly in the third trimester due to risks of fetal harm.
- Children: Not recommended for individuals under 18 years due to lack of clinical data on safety and efficacy.
Drug Interactions
Aceclofenac may interact with other medications, particularly:
- Anticoagulants: Such as warfarin or acenocoumarol, increasing the risk of bleeding.
- Other NSAIDs: Concurrent use should be avoided unless directed by a healthcare provider.
