Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used to relieve pain and inflammation associated with various conditions, including osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It works by inhibiting the cyclooxygenase (COX) enzymes, which play a key role in the production of prostaglandins—chemicals responsible for pain and inflammation.
Indications
Aceclofenac is indicated for:
- Osteoarthritis: Relief of joint pain and inflammation.
- Rheumatoid Arthritis: Management of chronic inflammatory symptoms.
- Ankylosing Spondylitis: Alleviation of stiffness and pain.
Dosage
The standard dosage for adults is generally:
- 200 mg daily, taken as two separate doses (100 mg each), preferably after meals to minimize gastrointestinal irritation.
Warnings and Precautions
- Elderly Patients: Increased risk of renal impairment and gastrointestinal bleeding. Caution is advised due to potential age-related organ function decline.
- Pregnant Women: Should avoid use during pregnancy, particularly in the third trimester due to risks of fetal harm.
- Children: Not recommended for individuals under 18 years due to lack of clinical data on safety and efficacy.
Drug Interactions
Aceclofenac may interact with other medications, particularly:
- Anticoagulants: Such as warfarin or acenocoumarol, increasing the risk of bleeding.
- Other NSAIDs: Concurrent use should be avoided unless directed by a healthcare provider.
