Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) primarily used for the relief of pain and inflammation associated with various conditions, particularly osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Below are the medical descriptions, usage, side effects, and warnings related to Aceclofenac.
Medical Description
Active Ingredient: Aceclofenac
Formulation: 100 mg film-coated tablets
Classification: Non-steroidal anti-inflammatory drug (NSAID)
Indications
Aceclofenac is indicated for:
-Osteoarthritis: Helps relieve pain and improve joint function.
-Rheumatoid Arthritis: Reduces inflammation and pain in chronic inflammatory conditions.
-Ankylosing Spondylitis: Alleviates stiffness and pain associated with this condition.
Mechanism of Action
Aceclofenac works by inhibiting the cyclooxygenase (COX) enzymes, leading to a decrease in the production of prostaglandins—substances that mediate inflammation, pain, and fever. By blocking COX enzymes, Aceclofenac effectively reduces swelling and discomfort at the injury site.
Dosage
The typical dosage for adults is 200 mg daily, taken as two separate 100 mg doses (one in the morning and one in the evening), preferably after meals to minimize gastrointestinal irritation.
Warnings and Precautions
Elderly Patients: Increased risk of renal impairment, cardiovascular issues, and gastrointestinal bleeding. Caution is advised due to potential age-related organ function decline.
Pregnant Women: Should avoid use during pregnancy as it may harm fetal development. It is contraindicated especially in the third trimester due to risks of premature closure of the ductus arteriosus
Children: Not recommended for use in individuals under 18 years due to insufficient clinical data on safety and efficacy
Drug Interactions
Aceclofenac may interact with other medications, particularly blood thinners (e.g., warfarin) and other NSAIDs, which can increase the risk of bleeding. Patients should inform their healthcare provider about all medications they are taking.
