Nicergoline is used in Acute migraine headache and Raynaud's disease. Nicergoline works by constricting (narrowing) these blood vessels, thereby relieving the migraine headaches. Nicergoline decreases vascular resistance and increases arterial blood flow, improving the utilization of oxygen and glucose by the blood vessels as well as other areas of the body. It also prevents platelet aggregation which coagulates the blood excessively, giving rise to blood clots and interfering with the blood circulation.