🧬 SLU-PP-332 – Exercise-Mimetic Peptide for Metabolic & Regenerative Research
Synonyms: Pan-ERR Agonist, Exercise-Mimetic Peptide
CAS Number: N/A (investigational compound)
Molecular Formula: Proprietary
Molecular Weight: ~1.2–3.5 kDa (estimated range)
Form: Lyophilized powder or sublingual tablet (varies by supplier)
Purity: ≥98% (HPLC)
Research Use Only. Not for human consumption.
---
📖 Description:
SLU-PP-332 is a synthetic peptide-like compound developed at Saint Louis University, designed to activate estrogen-related receptors (ERRα/β/γ)—key regulators of mitochondrial biogenesis, fatty acid oxidation, and energy metabolism. It is under active investigation as a non-hormonal exercise mimetic, with potential applications in metabolic health, muscle regeneration, and anti-inflammatory modulation.
Unlike traditional stimulants or hormonal agents, SLU-PP-332 mimics the molecular effects of aerobic exercise without requiring physical exertion, making it a promising candidate for obesity, sarcopenia, and metabolic syndrome research.
---
⚙️ Mechanism of Action:
SLU-PP-332 acts as a pan-ERR agonist, particularly targeting ERRα, to induce exercise-like adaptations:
• Mitochondrial Biogenesis: Increases mitochondrial density and respiratory efficiency
• Fatty Acid Oxidation: Enhances lipid metabolism and thermogenesis
• Muscle Fiber Remodeling: Promotes oxidative Type I/IIa fiber expression
• Anti-Inflammatory Effects: Downregulates TNF-α and IL-6 in metabolic tissues
• Circadian Modulation: Activates REV-ERB pathways for metabolic rhythm alignment
• Cardioprotection: Improves ejection fraction and reduces cardiac fibrosis in preclinical models
---
📈 Research Applications:
SLU-PP-332 is being explored in preclinical and in vitro models for:
• Obesity & Fat Loss: Reduces adiposity without altering food intake
• Exercise Performance: Increases endurance capacity and VO₂ max in animal models
• Muscle Recovery: Enhances satellite cell activation and muscle fiber repair
• Metabolic Syndrome: Improves insulin sensitivity and glucose tolerance
• Cardiovascular Health: Supports mitochondrial function in cardiac tissue
• Neuroinflammation: Investigated for mitochondrial support in CNS models
Its non-stimulant, non-hormonal profile makes it suitable for long-term metabolic and regenerative research.
---
📦 Packaging & Handling:
• Supplied as a sterile-filtered lyophilized peptide or sublingual tablet
• Store at –20°C, protected from light and moisture
• Reconstitute with bacteriostatic water or appropriate buffer (if in powder form)
• For sublingual tablets: store in a cool, dry place
• Stable for up to 14 days at 2–8°C
