FOXO4-DRI (Retro-Inverso) is a synthetic, modified peptide derived from the FOXO4 transcription factor. The retro-inverso design (D-amino acids arranged in reverse sequence) dramatically increases stability and extends its biological half-life, enabling more effective interaction with cellular targets.
Its primary mechanism involves competitively blocking the natural binding between FOXO4 and the tumor suppressor protein p53. In normal aging tissues, FOXO4 helps retain p53 in the nucleus of senescent cells, preventing them from undergoing apoptosis. By disrupting this FOXO4–p53 interaction, FOXO4-DRI releases p53’s apoptotic signaling pathway, allowing damaged and dysfunctional senescent “zombie” cells to be selectively cleared.
Removal of these senescent cells has been shown in research models to:
restore tissue structure and function
decrease chronic low-grade inflammation
improve organ performance and metabolic health
support enhanced vitality and physical resilience
potentially reverse certain biomarkers of biological aging
Beyond its senolytic activity, studies suggest FOXO4-DRI may influence pathways tied to oxidative stress, insulin sensitivity, mitochondrial function, and cell-cycle regulation—making it a notable candidate in longevity, regenerative medicine, and age-related disease research.
For research use only. Refer to the product Certificate of Analysis for the exact product specifications
Batch FOX101125 purity/net content/endotoxin/heavy metal analysis
https://chromate.org/verify?c=29549_SQ736YYJH2L6Technical SpecificationsProduct Name:FOXO4-DRI 10mg
Form: lyophilized powder
Purity: >99%
Verification: Qualitative and quantitative chemical analysis by Reverse-phase HPLC with UV Detection. Endotoxicology verified using kinetic chromogenic LAL assay.
Packaging: (1) 3ml vial sealed with rubber stopper and aluminum crimp seal. Packaged in light-shielding box.
Storage Conditions: Store at 2–8°C. Protect from light and moisture. Keep tightly sealed.
Stability: Stable for 36 months under proper storage conditions
Intended Use
This product is intended strictly for qualified laboratory researchers. It is not for human or veterinary consumption and must not be used as a drug, food additive, cosmetic, or household item.
⚠️ Disclaimer:
This compound is sold for in vitro research and educational purposes only. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. All buyers must be authorized research personnel or institutions.
Terms of Sale:
By purchasing this product, you confirm that you are a qualified professional conducting lawful scientific research. Orbitrex Peptides and its affiliates are not liable for any misuse or mishandling of this material.
Choose Orbitrex Peptides. Choose FOXO4-DRI 10mg. Choose confidence in every step of your research journey.
SKU: 59-FOX101125
