Retatrutide is a synthetic peptide that works as a triple agonist, activating three key hormone receptors:
- GLP-1 (Glucagon-Like Peptide-1): regulates appetite and glucose metabolism
- GIP (Glucose-Dependent Insulinotropic Polypeptide): enhances insulin secretion and glucose reuptake
- Glucagon: increases energy expenditure and promotes fat breakdown
Benefits
Retatrutide has shown promising results in clinical trials, including ¹ ² ³:
- Significant weight loss: up to 24% body weight loss in 48 weeks
- Improved glycemic control: reduced HbA1c levels and improved insulin sensitivity
- Enhanced fat metabolism: increased fat breakdown and improved liver health
Dosage and Administration
The typical dosage schedule for retatrutide involves gradual dose escalation ⁴ ⁵ ³:
- Starting dose: 0.5-2.5mg per week
- Mid-titration dose: 4-10mg per week
- Advanced titration dose: 8-12mg per week
- Maintenance dose: 5-10mg per week
