GHK-Cu (GHK-CU) is a naturally occurring copper(II) complex of the tripeptide Gly–His–Lys, composed of three amino acids. In non-clinical laboratory settings, it is used in controlled in vitro studies to investigate extracellular matrix signalling, collagen pathways, cell-surface interactions, wound healing processes, tissue regeneration, and antioxidant activity. For research purposes, it is commonly dosed at 50mg.
This complex forms when the tripeptide GHK chelates Cu(II). Because of its coordination chemistry and peptide motif, researchers employ it to probe matrix-associated readouts, peptide–metal interactions, and receptor-adjacent signalling in model systems.
